Chemical name:
Molecular weight:
949,06*79,90 g/mol
on request


A synthetic cyclic RGD peptide induces the formation of multicellular tumor spheroids (MTS) – 3D in vitro models that mimic the in vivo tumor environment. Cyclo-RGDfK(TPP) induces self-assembly into 3D spheroids in certain cell lines including tumor normal and stem cells. Those spheroids are valuable tools for drug screening, as well as for tissue regeneration experiments.


  1. 3D in vitro co-culture models based on normal cells and tumor spheroids formed by cyclic RGD-peptide induced cell self-assembly; R. Akasov, A. Gileva, D. Zaytseva-Zotova, S. Burov, I. Chevalot, E. Guedon and E. Markvicheva; Biotechnology Letters 2017; 39: 45-53. DOI:10.1007/s10529-016-2218-9
  2. Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide; S. Haq, V. Samuel, F. Haxho, R. Akasov, M. Leko, S. V. Burov, E. Markvicheva, M. R. Szewczuk; OncoTargets and therapy 2017; 10: 2427-2447. DOI:10.2147/ott.s133563
  3. Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly; R. Akasov, S. Haq, F. Haxho, V. Samuel, S. V. Burov, E. Markvicheva, R. J . Neufeld and M. R. Szewczuk; Oncotarget 2016; 7: 66119-66134. DOI:10.18632/oncotarget.11868
  4. Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro; R. Akasov, D. Zaytseva-Zotova, S. Burov, M. Leko, M. Dontenwill, M. Chiper, T. Vandamme and E. Markvicheva; International Journal of Pharmaceutics 2016; 506: 148-157. DOI: 10.1016/j.ijpharm.2016.04.005