cyclo[RGDfK(TPP)]
Chemical name:
cyclo[-Arg-Gly-Asp-D-Phe-Lys(TPP)]
Cas-no.:
1926210-57-2
Formula:
Molecular weight:
949,06*79,90 g/mol
Quantity:
Price:
on request
Application
A synthetic cyclic RGD peptide induces the formation of multicellular tumor spheroids (MTS) – 3D in vitro models that mimic the in vivo tumor environment. Cyclo-RGDfK(TPP) induces self-assembly into 3D spheroids in certain cell lines including tumor normal and stem cells. Those spheroids are valuable tools for drug screening, as well as for tissue regeneration experiments.
References
- 3D in vitro co-culture models based on normal cells and tumor spheroids formed by cyclic RGD-peptide induced cell self-assembly; R. Akasov, A. Gileva, D. Zaytseva-Zotova, S. Burov, I. Chevalot, E. Guedon and E. Markvicheva; Biotechnology Letters 2017; 39: 45-53. DOI:10.1007/s10529-016-2218-9
- Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide; S. Haq, V. Samuel, F. Haxho, R. Akasov, M. Leko, S. V. Burov, E. Markvicheva, M. R. Szewczuk; OncoTargets and therapy 2017; 10: 2427-2447. DOI:10.2147/ott.s133563
- Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly; R. Akasov, S. Haq, F. Haxho, V. Samuel, S. V. Burov, E. Markvicheva, R. J . Neufeld and M. R. Szewczuk; Oncotarget 2016; 7: 66119-66134. DOI:10.18632/oncotarget.11868
- Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro; R. Akasov, D. Zaytseva-Zotova, S. Burov, M. Leko, M. Dontenwill, M. Chiper, T. Vandamme and E. Markvicheva; International Journal of Pharmaceutics 2016; 506: 148-157. DOI: 10.1016/j.ijpharm.2016.04.005