A synthetic cyclic RGD peptide induces the formation of multicellular tumor spheroids (MTS) – 3D in vitro models that mimic the in vivo tumor environment. Cyclo-RGDfK(TPP) induces self-assembly into 3D spheroids in certain cell lines including tumor normal and stem cells. Those spheroids are valuable tools for drug screening, as well as for tissue regeneration experiments.
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- Sialylation facilitates self-assembly of 3D multicellular prostaspheres by using cyclo-RGDfK(TPP) peptide; S. Haq, V. Samuel, F. Haxho, R. Akasov, M. Leko, S. V. Burov, E. Markvicheva, M. R. Szewczuk; OncoTargets and therapy 2017; 10: 2427-2447. DOI:10.2147/ott.s133563
- Sialylation transmogrifies human breast and pancreatic cancer cells into 3D multicellular tumor spheroids using cyclic RGD-peptide induced self-assembly; R. Akasov, S. Haq, F. Haxho, V. Samuel, S. V. Burov, E. Markvicheva, R. J . Neufeld and M. R. Szewczuk; Oncotarget 2016; 7: 66119-66134. DOI:10.18632/oncotarget.11868
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