This cyclic RGD peptide possesses a high affinity to αvβ3 receptors on neovascular blood vessels of different major human cancers.
This cyclic RGD peptide possesses a high affinity to integrin receptors localized on the surface of cancer cells. It can be easily conjugated to dyes, drug molecules, or chelators, like DOTA and NOTA.
A synthetic cyclic RGD peptide induces the formation of multicellular tumor spheroids – 3D in vitro models that mimic the in vivo tumor environment. It initiates self-assembly in different cell lines including tumor, normal and stem cells. 3D spheroids are valuable tools for drug screening as well as for tissue regeneration experiments.
Hydrazone resin provides a new and convenient method for the synthesis of peptide hydrazides, which can be applied during the ligation technique. This polymeric carrier permits to obtain the desired peptides in reasonable yields and purity.
Preloaded hydrazone resins
The use of preloaded resins is more convenient, permits to save time and in certain cases circumvents the racemization issues.
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